Roth, a first-generation Canadian, was born in Woodstock, Ontario, to a Scottish father and a Dutch mother.
She debuted in the Canadian horror film The Club (1994), directed by Brenton Spencer, and appeared in numerous television series and TV movies before landing her role on Rescue Me. Her other long role was that of Diana/NeuroBrain in RoboCop: The Series, who appeared in all episodes. Roth also appeared in the Jet Li action film War (2007). Furthermore, she guest-starred on Blue Bloods and Ringer.
On March 29, 2010, Roth and her boyfriend Todd Biermann gave birth to a daughter named Ava Reese. The couple married on October 7, 2011.