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Taylor-Klaus was born in Atlanta, Georgia on August 12, to a Jewish family. They began acting by performing Shakespeare in an after-school program while in the 3rd grade, and it became a consistent part of their extracurricular and summer activities. They performed in their high school's improvisation troupe. Working with friends, they also started a Junior-High Acting Troupe to train young actors. In addition to drama, Taylor-Klaus was an accomplished athlete: they were the starting catcher on the high school's varsity softball team while a freshman, and also played 3rd base. They have two siblings; Syd Taylor-Klaus and Josh Taylor-Klaus. In mid-2012, Taylor-Klaus moved to Los Angeles to pursue an acting career. While they were in Los Angeles, they attended Bridges Academy.
Taylor-Klaus began acting in Shakespeare plays while in the third grade. However, their first professional acting role was that of Bullet, a homeless street-wise lesbian teen, on the third season of the AMC crime drama series The Killing, which aired in 2013. A breakout star playing a gender fluid lesbian, they quickly gained a cult following. Writing about playing Bullet, they said: "to be an actor is to want to visit the dark places that humans strive so hard to stay away from.”
From 2013 to 2015, Taylor-Klaus played the recurring role of Sin in The CW superhero drama series Arrow.
Taylor-Klaus gained further success with their starring role of Audrey Jensen, a bi-curious teenager helping her friends investigate a serial killer, in the first two seasons of the MTV horror drama series Scream. They appeared on the series from 2015 to 2016.
After gaining prominence from their roles in The Killing and Arrow, they went on to play several guest roles in numerous television series, including Glee and iZombie. In 2016, they began voicing the starring role of Katie "Pidge" Holt in the cult Netflix animated series Voltron: Legendary Defender.
Taylor-Klaus had a starring role as Taylor in the slasher horror film Hell Fest (2018) They also star as Hannah Perez in the musical comedy film Dumplin', which is a film adaptation of Julie Murphy’s New York Times bestselling young adult novel. The film, which co-stars Jennifer Aniston, is directed by Anne Fletcher. Taylor-Klaus will play Violette Paich in Mario Sorrenti’s horror film Discarnate.
- They're engaged to fellow actress Alicia Sixtos.